A Population Shift between Sparsely Populated Folding Intermediates Determines Amyloidogenicity
نویسندگان
چکیده
منابع مشابه
A Population Shift between Sparsely Populated Folding Intermediates Determines Amyloidogenicity
The balance between protein folding and misfolding is a crucial determinant of amyloid assembly. Transient intermediates that are sparsely populated during protein folding have been identified as key players in amyloid aggregation. However, due to their ephemeral nature, structural characterization of these species remains challenging. Here, using the power of nonuniformly sampled NMR methods w...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2016
ISSN: 0002-7863,1520-5126
DOI: 10.1021/jacs.6b02464